Description

5-Fluoro-2-(Pyrrolidin-2-Ylmethoxy)-Pyrimidine Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant interest in modern drug discovery. Its molecular structure, featuring a fluorinated pyrimidine core linked to a pyrrolidine moiety, makes it a valuable scaffold for the synthesis of novel bioactive compounds. This material is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) research.
• Kinase Inhibitor Development: Used in the research and development of small molecule kinase inhibitors due to its privileged pyrimidine-based structure.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and cellular signaling pathways.
• Agrochemical Research: Acts as a precursor in the discovery of new active ingredients for crop protection products.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for medicinal chemistry programs and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Sourced for process optimization and pilot-scale synthesis during the transition from research to development phases.

Basic Information

Product Name	5-Fluoro-2-(Pyrrolidin-2-Ylmethoxy)-Pyrimidine Hydrochloride
CAS No.	1261235-88-4
Molecular Formula	C9H13FN3O•HCl
Molecular Weight	231.68 g/mol (Free base: 195.22 g/mol)
Synonyms	5-Fluoro-2-[(2-pyrrolidinyl)methoxy]pyrimidine hydrochloride; 2-((Pyrrolidin-2-yl)methoxy)-5-fluoropyrimidine HCl; 5-Fluoro-2-(pyrrolidin-2-ylmethoxy)pyrimidine hydrochloride; 1261235-88-4; 5-Fluoro-2-(2-pyrrolidinylmethoxy)pyrimidine monohydrochloride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Pyrrolidin-2-Ylmethoxy)-Pyrimidine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.