Description

(+)-Yk-4-279 CAS NO 1261038-93-0 is a high-purity, enantiomerically pure small molecule compound of significant interest in pharmaceutical research and development. This compound serves as a potent and selective inhibitor of RNA helicase A (RHA/DHX9), a key target in oncology and virology research. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in drug discovery programs. Its specific activity makes it a critical tool for studying cancer biology, viral replication mechanisms, and developing novel therapeutic agents.

Application

• Oncology Research: Used as a chemical probe to study the role of RNA helicase A (DHX9) in cancer cell proliferation, metastasis, and apoptosis.
• Antiviral Drug Discovery: Investigated for its potential to inhibit viral replication by targeting host factors like DHX9, relevant for HIV and other viruses.
• Biochemical Assay Development: Serves as a reference standard and active control in high-throughput screening (HTS) campaigns and enzymatic assays.
• Preclinical Studies: Employed in in vitro and in vivo models to validate DHX9 as a therapeutic target and assess compound efficacy.
• Medicinal Chemistry: Used as a lead compound or building block for the synthesis and optimization of novel DHX9 inhibitor analogs.
• Signal Transduction Research: A tool for dissecting the DHX9-mediated signaling pathways involved in cellular stress response and gene expression.

Basic Information

Product Name	(+)-Yk-4-279
CAS No.	1261038-93-0
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	(+)-YK 4-279; YK-4-279 enantiomer; (R)-N-[3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1H-pyrazol-5-yl]-4-[(6-methyl-2-pyridinyl)amino]benzamide; DHX9 Inhibitor; RNA Helicase A Inhibitor; RHA Inhibitor
EINECS	Contact for details

Quality Control

Our (+)-Yk-4-279 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with research-grade standards. Stability data is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.