Description

Ethyl 5-(Trifluoromethyl)Imidazo[1,2-A]Pyridine-2-Carboxylate is a high-value heterocyclic building block featuring a fused imidazopyridine core with a strategically positioned trifluoromethyl group. This compound is essential for medicinal chemistry research and development, offering significant potential for modulating the physicochemical and pharmacokinetic properties of lead candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology, CNS disorders, and anti-infective therapies.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization, leveraging the properties of the trifluoromethyl group to enhance metabolic stability and lipophilicity.
• Agrochemical Research: Serves as a precursor in the development of advanced pesticides and herbicides, where the imidazopyridine scaffold can contribute to novel modes of action.
• Material Science Exploration: Investigated as a component in the synthesis of specialty chemicals and advanced organic materials, including ligands for catalysis.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects and scale-up activities.

Basic Information

Item	Details
Product Name	Ethyl 5-(Trifluoromethyl)Imidazo[1,2-A]Pyridine-2-Carboxylate
CAS No.	1260885-46-8
Molecular Formula	C11H9F3N2O2
Molecular Weight	258.20 g/mol
Synonyms	Ethyl 5-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate; 5-(Trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester; Imidazo[1,2-a]pyridine-2-carboxylic acid, 5-(trifluoromethyl)-, ethyl ester; 1260885-46-8; Ethyl 5-(trifluoromethyl)-imidazo[1,2-a]pyridine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 5-(Trifluoromethyl)Imidazo[1,2-A]Pyridine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.