Description

(R)-5-Fluoro-2-Methoxy-3-(Pyrrolidin-2-Yl)Pyridine Dihydrochloride is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and functionalized pyridine-pyrrolidine core, which is critical for the synthesis of targeted bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Key chiral intermediate in the research and development of new active pharmaceutical ingredients (APIs).
• Building block for the synthesis of small molecule inhibitors targeting specific kinases or receptors.
• Precursor in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Used in the development of potential treatments for cancer and neurological disorders.
• Critical material for process chemistry and scale-up studies in pharmaceutical manufacturing.
• Reference standard for analytical method development and quality control in API production.

Basic Information

Product Name	(R)-5-Fluoro-2-Methoxy-3-(Pyrrolidin-2-Yl)Pyridine Dihydrochloride
CAS No.	1260845-81-5
Molecular Formula	C10H14F N2O • 2HCl
Molecular Weight	279.15 g/mol (Free base: 206.23)
Synonyms	(R)-5-Fluoro-2-Methoxy-3-(2-Pyrrolidinyl)Pyridine Dihydrochloride; (R)-3-(Pyrrolidin-2-yl)-5-Fluoro-2-Methoxypyridine Dihydrochloride; (R)-5-Fluoro-2-Methoxy-3-(2-Pyrrolidinyl)Pyridine Hydrochloride (1:2); (R)-5-Fluoro-2-Methoxy-3-(Pyrrolidin-2-yl)Pyridine 2HCl; UNII-6J3S8WY1QH; 6J3S8WY1QH
EINECS	Contact for details

Quality Control

Our (R)-5-Fluoro-2-Methoxy-3-(Pyrrolidin-2-Yl)Pyridine Dihydrochloride is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.