Description

1-(3-Fluoro-5-(Trifluoromethyl)Pyridin-2-Yl)Ethanone is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl groups, is engineered to impart desirable properties such as metabolic stability and enhanced lipophilicity to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Material Science Research: Acts as a precursor for synthesizing specialty chemicals, liquid crystals, and functional materials that require fluorinated aromatic systems.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes and enzyme inhibitors used in biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	1-(3-Fluoro-5-(Trifluoromethyl)Pyridin-2-Yl)Ethanone
CAS No.	1260763-90-3
Molecular Formula	C8H5F4NO
Molecular Weight	207.12 g/mol
Synonyms	2-Acetyl-3-fluoro-5-(trifluoromethyl)pyridine; 1-[3-Fluoro-5-(trifluoromethyl)-2-pyridinyl]ethanone; 3-Fluoro-5-(trifluoromethyl)pyridin-2-yl methyl ketone; 2-Acetyl-3-fluoro-5-trifluoromethylpyridine; Ethanone, 1-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-; 1260763-90-3
EINECS	Contact for details

Quality Control

Our production of 1-(3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)ethanone adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. Our quality management system is designed to support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.