Description

Coumarin Suberoylanilide Hydroxamic Acid CAS NO 1260635-77-5 is a specialized hydroxamic acid derivative that serves as a potent and selective inhibitor of histone deacetylase (HDAC) enzymes. This compound is of significant value in biochemical research for its role in modulating gene expression and cellular processes. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology, epigenetics, and drug discovery.

Application

• Biochemical Research: Used as a reference standard and active compound in studies of histone deacetylase (HDAC) inhibition and epigenetic regulation.
• Pharmaceutical Development: Serves as a key intermediate or pharmacophore in the discovery and synthesis of novel anti-cancer therapeutics.
• Cell Biology Studies: Applied in vitro to investigate the effects of HDAC inhibition on cell proliferation, differentiation, and apoptosis.
• Enzyme Assay Kits: Utilized as a critical component in high-throughput screening (HTS) kits to identify and characterize new HDAC inhibitors.
• Academic Research: Employed in universities and research institutes for fundamental studies in chromatin biology and gene expression control.

Basic Information

Product Name	Coumarin Suberoylanilide Hydroxamic Acid
CAS No.	1260635-77-5
Molecular Formula	C₂₅H₂₈N₂O₅
Molecular Weight	436.50 g/mol
Synonyms	Coumarin-SAHA; Coumarin-conjugated SAHA; CSHA; N1-Hydroxy-N8-(7-((2-oxo-2H-chromen-4-yl)oxy)heptyl)octanediamide; HDAC Inhibitor with Coumarin Fluorophore; Fluorescent HDAC Inhibitor; SAHA-Coumarin Conjugate
EINECS	Contact for details

Quality Control

Our Coumarin Suberoylanilide Hydroxamic Acid is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliable performance in your assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.