Description

Phenylephrine 2-o-Glucuronide is a major, stable phase II metabolite of the common decongestant and vasopressor agent, phenylephrine. This compound is of critical importance for pharmaceutical research and development, serving as a key reference standard for bioanalytical studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in pharmacokinetic profiling, drug metabolism and excretion studies, and the development of validated analytical methods.

Application

• Pharmacokinetic and Bioanalytical Research: Used as a certified reference standard for quantifying phenylephrine and its metabolites in biological matrices (e.g., plasma, urine) via LC-MS/MS or HPLC.
• Drug Metabolism and Excretion (DMPK) Studies: Essential for mapping the metabolic pathways of phenylephrine, specifically glucuronidation, to understand drug clearance mechanisms.
• Method Development and Validation: Serves as a critical calibrant for developing, validating, and ensuring the regulatory compliance of analytical assays in clinical and pre-clinical trials.
• Toxicology and Safety Assessment: Employed in studies to investigate the safety profile and potential interactions of phenylephrine metabolites.
• Quality Control in Pharmaceutical Manufacturing: Acts as a system suitability standard to ensure the accuracy and precision of analytical equipment used in quality control laboratories.

Basic Information

Product Name	Phenylephrine 2-o-Glucuronide
CAS No.	1260611-56-0
Molecular Formula	C16H23NO8
Molecular Weight	357.36 g/mol
Synonyms	Phenylephrine O-β-D-Glucuronide; (R)-3-[1-Hydroxy-2-(methylamino)ethyl]phenyl β-D-Glucopyranosiduronic Acid; Phenylephrine Glucuronide; 1-(3-Hydroxyphenyl)-2-(methylamino)ethanol Glucuronide; m-Hydroxy-α-[(methylamino)methyl]benzyl Alcohol Glucuronide; Phenylephrine 2-O-β-D-Glucuronide; Phenylephrine Major Metabolite
EINECS	Contact for details

Quality Control

Our Phenylephrine 2-o-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for reference material applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.