Description

Trandolaprilat Acyl--D-Glucuronide, 65% CAS NO 1260610-97-6 is a high-purity reference standard and key metabolite of the ACE inhibitor trandolapril, essential for accurate pharmacokinetic and metabolic profiling studies. This compound is critical for pharmaceutical R&D and quality control laboratories requiring definitive analytical standards for method development and validation. It is primarily utilized by researchers and analytical chemists in the pharmaceutical, contract research organization (CRO), and bioanalytical sectors.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of trandolapril and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, bioavailability, and clearance rates of trandolapril in preclinical and clinical research.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS assays for therapeutic drug monitoring and pharmacokinetic studies.
• Impurity Profiling and Characterization: Acts as a known metabolite impurity standard to ensure drug substance and product purity according to ICH guidelines.
• Regulatory Submission Support: Provides critical data for regulatory filings (e.g., FDA, EMA) by enabling precise metabolite identification and quantification.
• In-vitro Metabolism Studies: Utilized in hepatocyte or microsomal incubation experiments to elucidate phase II glucuronidation conjugation pathways.

Basic Information

Item	Detail
Product Name	Trandolaprilat Acyl--D-Glucuronide, 65%
CAS No.	1260610-97-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Trandolaprilat Acyl Glucuronide; Trandolapril Metabolite; (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid β-D-Glucopyranosiduronic acid; Trandolapril Acyl-β-D-Glucuronide; Trandolapril Glucuronide Metabolite
EINECS	Contact for details

Quality Control

Our Trandolaprilat Acyl--D-Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC purity analysis and spectroscopic identification (NMR, MS), to ensure identity, strength, and composition. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 65%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.