Description

Acemetacin Acyl-β-D-Glucuronide is a key metabolite and reference standard for the non-steroidal anti-inflammatory drug (NSAID) acemetacin. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery and regulatory compliance activities.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of acemetacin and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, bioavailability, and excretion profiles of acemetacin.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and clinical studies.
• Impurity Profiling: Employed as a marker to identify and quantify glucuronidated impurities or metabolites in active pharmaceutical ingredient (API) batches.
• Toxicological Research: Aids in understanding the safety profile and potential side effects associated with acemetacin metabolism.

Basic Information

Product Name	Acemetacin Acyl-β-D-Glucuronide
CAS No.	1260603-31-3
Molecular Formula	C26H31NO12
Molecular Weight	549.52 g/mol
Synonyms	Acemetacin Glucuronide; Acemetacin 1-O-Acyl-β-D-Glucuronide; [[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]-β-D-glucopyranosiduronic Acid; Acemetacin Acylglucuronide; Acemetacin Metabolite; 1-O-Acemetacin-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Acemetacin Acyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch is characterized and tested to ensure high purity and consistency, suitable for use as a reference standard. Comprehensive analytical testing includes identification (HPLC, MS), purity assay, and control of related substances. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.