Description

Lecanemab CAS NO 1260393-98-3 is a humanized monoclonal antibody designed to selectively target and clear amyloid-beta protofibrils. This compound is of paramount importance in the research and development of novel therapeutics for neurodegenerative conditions. It is primarily required by pharmaceutical R&D teams, clinical research organizations, and academic institutions focused on Alzheimer's disease and related pathologies.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in formulated drug products for clinical and commercial use.
• Biomedical Research: Critical tool for in vitro and in vivo studies investigating the mechanisms of amyloid-beta aggregation and clearance.
• Preclinical & Clinical Development: Serves as the reference standard in pharmacokinetic, pharmacodynamic, and toxicology studies during drug development stages.
• Diagnostic Assay Development: Used in the development and calibration of immunoassays and other diagnostic tests targeting amyloid-beta species.
• Reference Standard: Acts as a high-purity standard for quality control and analytical method validation in GMP manufacturing.
• Therapeutic Antibody Engineering: Provides a basis for further protein engineering and the development of next-generation biologic therapies.

Basic Information

Product Name	Lecanemab
CAS No.	1260393-98-3
Molecular Formula	C6452H9916N1704O2018S46
Molecular Weight	~145 kDa
Synonyms	BAN2401; mAb158; Anti-Amyloid Beta Protofibril Antibody; LEQEMBI (trade name); Humanized IgG1 Monoclonal Antibody (anti-Aβ protofibril); AAB-003 (development code); LY3372993
EINECS	Contact for details

Quality Control

Our Lecanemab is manufactured under strict quality systems suitable for research and development applications. Quality is assured through a comprehensive battery of analytical tests including HPLC for purity and aggregation analysis, capillary electrophoresis for charge variants, and functional binding assays. Certificates of Analysis (COA) detailing lot-specific results for identity, purity, potency, and safety (endotoxin, bioburden) are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% Monomer
Purity (CE-SDS, reduced)	Heavy Chain & Light Chain bands present
Potency (SPR/BLI Binding)	Activity relative to reference standard
Protein Content (A280)	As per COA
Endotoxin	< 1.0 EU/mg
pH	6.0 - 7.5 (in solution)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.