Description

6-Amino-4-(Trifluoromethyl)Nicotinonitrile is a high-value, multi-functional heterocyclic building block characterized by its amino and nitrile functional groups on a trifluoromethylated pyridine core. This compound matters for its role in facilitating the rapid synthesis of complex molecules, particularly in pharmaceutical discovery and agrochemical research, where the trifluoromethyl group is prized for its ability to modulate lipophilicity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for functionalized ligands and organic frameworks in the development of specialty polymers and electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	6-Amino-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	1260382-03-3
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	4-(Trifluoromethyl)-6-aminonicotinonitrile; 6-Amino-4-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-4-(trifluoromethyl)pyridin-6-amine; 2-Amino-5-cyano-4-(trifluoromethyl)pyridine; 6-Amino-4-trifluoromethyl-3-pyridinecarbonitrile; 1260382-03-3 (CAS Name)
EINECS	Contact for details

Quality Control

Our 6-Amino-4-(Trifluoromethyl)Nicotinonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.