Description

(R)-Nornicotine-D4 is a stable isotope-labeled analog of the tobacco alkaloid nornicotine, specifically deuterated at four positions. This compound is of significant value as a high-purity internal standard and reference material for advanced analytical and metabolic studies. It is primarily required by research institutions and pharmaceutical companies engaged in pharmacokinetics, metabolite profiling, and forensic analysis of nicotine-related compounds.

Application

• Internal Standard for LC-MS/MS: Used for the precise quantification of nornicotine and related alkaloids in complex biological matrices.
• Metabolic Pathway Research: Enables the detailed tracing and identification of metabolites in in vitro and in vivo studies.
• Forensic Toxicology: Serves as a critical reference material for the accurate analysis of nicotine derivatives in forensic samples.
• Pharmaceutical Development: Supports drug metabolism and pharmacokinetics (DMPK) studies for novel therapeutics targeting nicotinic receptors.
• Reference Standard: Provides a certified benchmark for method development, validation, and quality control in analytical laboratories.
• Biochemical Research: Used in studies investigating the binding and function of nicotinic acetylcholine receptors.

Basic Information

Product Name	(R)-Nornicotine-D4
CAS No.	1259761-67-5
Molecular Formula	C9H8D4N2
Molecular Weight	150.22 g/mol (for deuterated form)
Synonyms	(R)-Nornicotine-d4; (R)-1,2,3,6-Tetradeuterio-2-(3-pyridyl)-1-pyrrolidine; (R)-Nornicotine (phenyl-D4); (R)-Nornicotine (tetradeuterated); (2R)-2-(Pyridin-3-yl)-1-pyrrolidine-d4; Deuterated (R)-Nornicotine; (R)-Nornicotine Internal Standard; Stable Isotope Labeled Nornicotine
EINECS	Contact for details

Quality Control

Our (R)-Nornicotine-D4 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by GC)	≥ 97.0%
Specific Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.