Description

Ski 178 is a high-purity specialty organic compound widely utilized as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemical actives. Its structural precision and batch-to-batch consistency enable reliable performance in demanding catalytic and coupling reactions, directly supporting regulatory compliance and process efficiency. Pharmaceutical R&D laboratories, custom synthesis contractors (CDMOs), and fine chemical manufacturers rely on Ski 178 CAS NO 1259484-97-3 for scalable, reproducible route development — particularly in nitrogen-containing heterocycle construction.

Application

• Key building block in the synthesis of kinase inhibitors and antiviral agents
• Intermediate for next-generation herbicides and plant growth regulators
• Coupling partner in palladium-catalyzed C–N cross-coupling reactions (e.g., Buchwald–Hartwig amination)
• Structural motif in PROTAC (Proteolysis-Targeting Chimera) linker design
• Raw material for high-value OLED host and electron-transport materials
• Chiral scaffold precursor in asymmetric synthesis of APIs

Basic Information

Product Name	Ski 178
CAS No.	1259484-97-3
Molecular Formula	C15H12F3N3O2
Molecular Weight	339.27 g/mol
Synonyms	SKI-178; N-(3-(Trifluoromethyl)phenyl)-2-(pyridin-4-yl)acetamide; 2-(4-Pyridyl)-N-(m-trifluoromethylphenyl)acetamide; SKI 178; SKI178; 2-(Pyridin-4-yl)-N-[3-(trifluoromethyl)phenyl]acetamide; MFCD22156712; N-(3-(Trifluoromethyl)phenyl)-2-(pyridin-4-yl)ethanamide
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches meet or exceed ACS Reagent Grade specifications for identity, assay, and residual solvent limits. Testing includes HPLC purity determination, IR and 1H-NMR confirmation, heavy metals screening (≤10 ppm), and water content (Karl Fischer, ≤0.5%). Full traceability and GMP-aligned documentation support global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Avoid exposure to strong acid/organic solvent and fluoride/strong alkali environments. Due to its light-sensitive nature, minimize handling under ambient lighting and use amber glass or opaque packaging for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Assay (HPLC)	≥99.5%
Identification (IR)	Conforms to reference standard
Identification (1H-NMR)	Conforms to reference standard
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.