Description

(S)-1-(2,3-Bis(Benzyloxy)Propyl)Cyclopropane-1-Sulfonyl Chloride is a high-purity chiral sulfonyl chloride building block of significant interest in advanced organic synthesis. Its core value lies in its role as a key electrophilic intermediate for introducing the cyclopropanesulfonamide moiety, a privileged structure in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical industry developing novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of chiral drug candidates, especially those containing cyclopropane sulfonamide pharmacophores.
• Protease Inhibitor Development: Used in research and development of inhibitors for various enzymes, leveraging the sulfonyl chloride's reactivity for covalent or high-affinity binding.
• Chemical Biology Probes: Serves as a versatile handle for labeling or modifying biomolecules to study protein function and interaction pathways.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening (HTS) against novel biological targets.
• Agrochemical Research: Employed in the synthesis of advanced, chiral active ingredients for crop protection with potential improved efficacy and selectivity.
• Material Science: Potential monomer or cross-linking agent for creating specialized polymers with unique thermal or mechanical properties.

Basic Information

Product Name	(S)-1-(2,3-Bis(Benzyloxy)Propyl)Cyclopropane-1-Sulfonyl Chloride
CAS No.	1258884-22-8
Molecular Formula	C20H23ClO4S
Molecular Weight	394.91 g/mol
Synonyms	(S)-1-[2,3-Bis(phenylmethoxy)propyl]cyclopropanesulfonyl chloride; (S)-1-(2,3-Di(benzyloxy)propyl)cyclopropane-1-sulfonyl chloride; (1S)-1-[2,3-Bis(benzyloxy)propyl]cyclopropane-1-sulfonyl chloride; (S)-Cyclopropanesulfonyl chloride, 1-[2,3-bis(phenylmethoxy)propyl]-; (S)-1-(2,3-Di-O-benzyl-1-propyl)cyclopropanesulfonyl chloride; Chiral Cyclopropanesulfonyl Chloride Derivative; Benzyl-Protected Glycerol Sulfonyl Chloride Derivative
EINECS	Contact for details

Quality Control

Our (S)-1-(2,3-Bis(Benzyloxy)Propyl)Cyclopropane-1-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and GMP-grade synthesis. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.