Description

2-(2,4-Difluorophenyl)Isonicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its difluorinated aromatic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity. It is primarily sought by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation medications.

Application

This specialized intermediate is engineered for precision applications in advanced chemical synthesis.

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Research: Serves as a building block for developing new-generation herbicides and pesticides with improved efficacy and environmental profiles.
• Material Science: Used in the research and development of advanced organic materials, including ligands for catalysts and monomers for specialty polymers.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies in both university and corporate laboratories.

Basic Information

Product Name	2-(2,4-Difluorophenyl)Isonicotinic Acid
CAS No.	1258627-10-9
Molecular Formula	C12H7F2NO2
Molecular Weight	235.19 g/mol
Synonyms	2-(2,4-Difluorophenyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-(2,4-difluorophenyl)-; Isonicotinic acid, 2-(2,4-difluorophenyl)-; 2-(2,4-Difluorophenyl)isonicotinate; 1258627-10-9; DFPA
EINECS	Contact for details

Quality Control

Our 2-(2,4-Difluorophenyl)Isonicotinic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.