Description

Ceramide Kinase Inhibitor, K1 is a potent and selective small molecule inhibitor of the enzyme ceramide kinase (CERK). This compound is a critical research tool for investigating the role of ceramide-1-phosphate (C1P) signaling pathways in cellular processes. It is primarily utilized by pharmaceutical researchers and life science companies for target validation and drug discovery programs focused on inflammation, immune regulation, and cancer biology.

Application

• Biochemical Research: Used as a selective inhibitor to study the function and signaling mechanisms of ceramide kinase (CERK) in vitro.
• Cell Biology Studies: Applied in cell-based assays to investigate the role of C1P in processes like cell proliferation, migration, and apoptosis.
• Drug Discovery & Target Validation: Serves as a key pharmacological probe for validating CERK as a therapeutic target in preclinical models of inflammatory and autoimmune diseases.
• Neuroscience Research: Utilized to explore the involvement of CERK and C1P in neuroinflammation and neurological disorders.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes conducting basic science on sphingolipid metabolism.

Basic Information

Product Name	Ceramide Kinase Inhibitor, K1
CAS No.	1258005-85-4
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	CERK Inhibitor K1; K1 Ceramide Kinase Inhibitor; NVP-231; 2-(4-Methylpiperazin-1-yl)-N-[5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]acetamide; (2-(4-Methylpiperazin-1-yl)-N-(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl)acetamide); CERK Inhibitor; Ceramide Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Ceramide Kinase Inhibitor, K1 is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.