Description

2-(Pyrrolidin-1-Yl)Pyridine-3-Boronic Acid is a specialized heterocyclic boronic acid derivative that serves as a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules, especially those containing pyridine and pyrrolidine pharmacophores for targets in oncology and CNS disorders.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Building block for constructing organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: Essential boronic acid reagent for forming carbon-carbon bonds between aromatic and heteroaromatic rings under mild conditions.
• Chemical Biology & Proteomics: Utilized in the development of chemical probes and enzyme inhibitors for biological pathway studies.
• Academic & Process R&D: Serves as a critical reagent for method development and scaling novel synthetic routes in research laboratories.

Basic Information

Product Name	2-(Pyrrolidin-1-Yl)Pyridine-3-Boronic Acid
CAS No.	1257648-75-1
Molecular Formula	C9H13BN2O2
Molecular Weight	192.03 g/mol
Synonyms	3-Pyridineboronic acid, 2-(1-pyrrolidinyl)-; 2-(Pyrrolidin-1-yl)-3-pyridinylboronic acid; 2-(1-Pyrrolidinyl)-3-pyridineboronic acid; 2-Pyrrolidin-1-ylpyridine-3-boronic acid; 2-(N-Pyrrolidino)pyridine-3-boronic acid; (2-(Pyrrolidin-1-yl)pyridin-3-yl)boronic acid; B-[2-(1-Pyrrolidinyl)-3-pyridinyl]boronic acid
EINECS	Contact for details

Quality Control

Our 2-(Pyrrolidin-1-Yl)Pyridine-3-Boronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.