Description

2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Amine is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for drug discovery, ligand synthesis, and the development of functional organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially in kinase inhibitor and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific fluorinated pyridine motifs.
• Material Science: Precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) and components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for studying biological processes.
• Catalyst & Ligand Development: Serves as a starting material for synthesizing novel bidentate ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Details
Product Name	2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Amine
CAS No.	1257554-30-5
Molecular Formula	C11H16BFN2O2
Molecular Weight	238.07 g/mol
Synonyms	3-Amino-2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine; 2-Fluoro-5-(pinacolatoboron)pyridin-3-amine; 3-Amino-2-fluoro-5-pyridineboronic acid pinacol ester; 5-Amino-6-fluoro-3-pyridylboronic acid pinacol ester; (3-Amino-2-fluoropyridin-5-yl)boronic acid pinacol ester; 1257554-30-5
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.