Description

(4-Fluoropyridin-2-Yl)Methanamine Dihydrochloride is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a functionalized amine handle on a fluorinated heterocyclic scaffold, enabling the development of novel compounds with targeted biological activity. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating new active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides, herbicides, and fungicides where the fluoropyridine moiety can enhance biological activity and environmental stability.
• Chemical Biology & Proteomics: Employed as a versatile linker or functional group for bioconjugation, probe development, and the study of protein-ligand interactions.
• Material Science: Acts as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for use in multi-step synthetic routes for client-specific projects requiring high-purity, complex intermediates.

Basic Information

Product Name	(4-Fluoropyridin-2-Yl)Methanamine Dihydrochloride
CAS No.	1257535-13-9
Molecular Formula	C6H8FCl2N2
Molecular Weight	195.04 g/mol
Synonyms	2-(Aminomethyl)-4-fluoropyridine dihydrochloride; 4-Fluoro-2-pyridinemethanamine dihydrochloride; (4-Fluoro-2-pyridinyl)methanamine dihydrochloride; 1-(4-Fluoropyridin-2-yl)methanamine dihydrochloride; 4-Fluoro-2-(aminomethyl)pyridine hydrochloride (1:2); (4-Fluoro-pyridin-2-yl)-methylamine dihydrochloride
EINECS	Contact for details

Quality Control

Our (4-Fluoropyridin-2-Yl)Methanamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.