Description

1-(2-Fluoro-5-Methylpyridin-3-Yl)Ethanone is a high-purity fluorinated pyridine derivative, a key building block in advanced organic synthesis. Its value lies in its unique molecular structure, which provides a reactive ketone group adjacent to a fluorinated heterocyclic system, enabling precise modifications for creating novel compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, particularly for candidates requiring fluorinated motifs to enhance metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A critical synthon for the research and development of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active molecule libraries.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atom and pyridine core contribute to improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for synthesizing specialized ligands, functionalized polymers, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for studying biological mechanisms and diagnostics.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	1-(2-Fluoro-5-Methylpyridin-3-Yl)Ethanone
CAS No.	1256836-29-9
Molecular Formula	C8H8FNO
Molecular Weight	153.15 g/mol
Synonyms	3-Acetyl-2-fluoro-5-methylpyridine; 2-Fluoro-5-methyl-3-acetylpyridine; 1-(2-Fluoro-5-methyl-3-pyridinyl)ethanone; Ethanone, 1-(2-fluoro-5-methyl-3-pyridinyl)-; 2-Fluoro-5-methylnicotinophenone; 3-Acetyl-2-fluoro-5-picoline
EINECS	Contact for details

Quality Control

Our 1-(2-Fluoro-5-Methylpyridin-3-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for every shipment, supporting your regulatory and R&D documentation needs. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.