Description

1-(5-Chloro-3-Fluoropyridin-2-Yl)Ethanone is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its precise molecular structure, which enables the introduction of key functional groups into complex target molecules. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the fluoropyridine moiety.
• Material Science Research: Serves as a precursor for the synthesis of specialized ligands, catalysts, and functionalized polymers.
• Chemical Biology: Employed as a molecular probe or a building block for labeled compounds in biochemical and pharmacological studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	1-(5-Chloro-3-Fluoropyridin-2-Yl)Ethanone
CAS No.	1256824-17-5
Molecular Formula	C7H5ClFNO
Molecular Weight	173.57 g/mol
Synonyms	2-Acetyl-5-chloro-3-fluoropyridine; 5-Chloro-3-fluoro-2-acetylpyridine; 1-(5-Chloro-3-fluoropyridin-2-yl)ethan-1-one; Ethanone, 1-(5-chloro-3-fluoro-2-pyridinyl)-; 2-Pyridineacetyl chloride, 5-chloro-3-fluoro-; 1256824-17-5
EINECS	Contact for details

Quality Control

Our production of 1-(5-Chloro-3-Fluoropyridin-2-Yl)Ethanone adheres to stringent quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, with specifications tailored to meet research and commercial development needs. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC or GC), identity confirmation (by IR, NMR), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.