Description

4-Bromo-2-(Trifluoromethyl)Nicotinaldehyde is a high-value, multi-functional chemical building block featuring both bromo and trifluoromethyl substituents on a nicotinaldehyde core. This compound matters for its critical role in facilitating complex molecular transformations, particularly in the synthesis of advanced pharmaceutical intermediates and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce halogenated and fluorinated motifs into heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the design of organic electronic materials and liquid crystals, where its specific halogen and fluorine pattern can tune electronic properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Fluorine Chemistry Exploration: Acts as a valuable model compound for studying the influence of the trifluoromethyl group on the reactivity and physicochemical properties of pyridine derivatives.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethyl)Nicotinaldehyde
CAS No.	1256822-45-3
Molecular Formula	C7H3BrF3NO
Molecular Weight	253.99 g/mol
Synonyms	4-Bromo-2-(trifluoromethyl)pyridine-3-carbaldehyde; 3-Formyl-4-bromo-2-(trifluoromethyl)pyridine; 4-Bromo-2-trifluoromethylnicotinaldehyde; 4-Bromo-2-trifluoromethyl-3-pyridinecarboxaldehyde; 4-Bromo-2-(trifluoromethyl)-3-pyridinecarbaldehyde; 1256822-45-3; 4-Bromo-2-(trifluoromethyl)nicotinaldehyde
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethyl)Nicotinaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.