Description

1-[6-(Difluoromethyl)Pyridin-3-Yl]Ethan-1-One is a high-purity, advanced pharmaceutical intermediate featuring a difluoromethyl-substituted pyridine core. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic and central nervous system disorders. It is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides where the difluoromethyl group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a starting material for creating specialized ligands and fluorinated organic frameworks.
• Chemical Biology Probes: Employed in the design of fluorinated probes and tags for studying biological mechanisms and protein interactions.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale production of target molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines.

Basic Information

Product Name	1-[6-(Difluoromethyl)Pyridin-3-Yl]Ethan-1-One
CAS No.	1256821-01-8
Molecular Formula	C8H7F2NO
Molecular Weight	171.15 g/mol
Synonyms	1-[6-(Difluoromethyl)-3-pyridinyl]ethanone; 1-(6-(Difluoromethyl)pyridin-3-yl)ethan-1-one; 3-Acetyl-6-(difluoromethyl)pyridine; 6-(Difluoromethyl)pyridin-3-yl methyl ketone; 6-(Difluoromethyl)nicotinoyl methyl; Ethanone, 1-[6-(difluoromethyl)-3-pyridinyl]-; 1-(6-(Difluoromethyl)-3-pyridyl)ethanone
EINECS	Contact for details

Quality Control

Our 1-[6-(Difluoromethyl)Pyridin-3-Yl]Ethan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We adhere to cGMP standards where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.