Description

2-(Difluoromethyl)Pyridine-3-Carboxylic Acid is a high-value fluorinated pyridine derivative, a key building block in modern synthetic chemistry. Its unique structure, featuring both a carboxylic acid and a difluoromethyl group on the pyridine ring, makes it an essential intermediate for creating compounds with enhanced biological activity and metabolic stability. This product is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can improve lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials that require specific fluorine-containing motifs for electronic or surface properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-(Difluoromethyl)Pyridine-3-Carboxylic Acid
CAS No.	1256809-21-8
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	3-Pyridinecarboxylic acid, 2-(difluoromethyl)-; 2-(Difluoromethyl)nicotinic acid; 2-Difluoromethylpyridine-3-carboxylic acid; 2-(Difluoromethyl)-3-pyridinecarboxylic acid; 1256809-21-8; Nicotinic acid, 2-(difluoromethyl)-; AI3-32845
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)Pyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.