Description

Methyl 2-(Difluoromethyl)-6-Methoxyisonicotinate is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoromethyl and methoxy substitution pattern makes it an essential intermediate for developing novel active ingredients with enhanced properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can improve metabolic stability and bioavailability.
• Material Science: Building block for creating specialty polymers and liquid crystals that require specific fluorine-containing motifs for performance enhancement.
• Chemical Synthesis: Versatile synthon for introducing the 2-(difluoromethyl)-6-methoxypyridine moiety into more complex molecular architectures in medicinal and process chemistry.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and scale-up projects for clients in life sciences.

Basic Information

Item	Details
Product Name	Methyl 2-(Difluoromethyl)-6-Methoxyisonicotinate
CAS No.	1256807-01-8
Molecular Formula	C9H9F2NO3
Molecular Weight	217.17 g/mol
Synonyms	Methyl 2-(difluoromethyl)-6-methoxypyridine-4-carboxylate; 6-Methoxy-2-(difluoromethyl)isonicotinic acid methyl ester; 2-(Difluoromethyl)-6-methoxy-4-pyridinecarboxylic acid methyl ester; Methyl 6-methoxy-2-(difluoromethyl)isonicotinate; 4-Pyridinecarboxylic acid, 2-(difluoromethyl)-6-methoxy-, methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-(Difluoromethyl)-6-Methoxyisonicotinate is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard research-grade material meets high-purity specifications suitable for advanced R&D applications. A detailed Certificate of Analysis (COA) documenting purity (typically by HPLC/NMR), identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.