Description

(5-(Difluoromethyl)Pyridin-2-Yl)Methanamine is a high-value pyridine derivative featuring a difluoromethyl substituent, a structural motif of significant interest in modern synthetic chemistry. This compound serves as a versatile and critical pharmaceutical intermediate and agrochemical building block, enabling the introduction of fluorine atoms to modulate the biological activity, metabolic stability, and lipophilicity of target molecules. It is essential for R&D and production teams in the pharmaceutical, agrochemical, and advanced material sectors seeking to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials that require fluorinated pyridine units.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services for clients in life sciences.

Basic Information

Product Name	(5-(Difluoromethyl)Pyridin-2-Yl)Methanamine
CAS No.	1256806-69-5
Molecular Formula	C7H8F2N2
Molecular Weight	158.15 g/mol
Synonyms	2-(Aminomethyl)-5-(difluoromethyl)pyridine; 5-(Difluoromethyl)-2-pyridinemethanamine; (5-(Difluoromethyl)-2-pyridinyl)methanamine; 2-Pyridinemethanamine, 5-(difluoromethyl)-; 5-(Difluoromethyl)pyridin-2-ylmethylamine; (5-Difluoromethyl-pyridin-2-yl)-methylamine; 2-(Aminomethyl)-5-(difluoromethyl)pyridine hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our (5-(Difluoromethyl)Pyridin-2-Yl)Methanamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with each shipment. We support compliance with ICH guidelines and can tailor specifications to meet the requirements of pharmaceutical (GMP) and agrochemical regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.