Description

1-(5-Difluoromethyl-Pyridin-3-Yl)-Ethanone is a high-purity, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular structure, which introduces both a ketone and a difluoromethyl group onto the pyridine ring, enabling precise modifications in target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors or CNS-active molecules.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoromethyl group can enhance biological activity and metabolic stability.
• Material Science Research: Employed in the synthesis of specialized ligands, catalysts, or fluorinated organic materials for electronic or optical applications.
• Chemical Biology Probes: Serves as a precursor for developing fluorinated probes and tags used in bioimaging and mechanism-of-action studies.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses serving the fine chemical and life science industries.

Basic Information

Product Name	1-(5-Difluoromethyl-Pyridin-3-Yl)-Ethanone
CAS No.	1256786-87-4
Molecular Formula	C8H7F2NO
Molecular Weight	171.15 g/mol
Synonyms	1-(5-(Difluoromethyl)pyridin-3-yl)ethan-1-one; 3-Acetyl-5-(difluoromethyl)pyridine; 5-(Difluoromethyl)pyridin-3-yl methyl ketone; Ethanone, 1-[5-(difluoromethyl)-3-pyridinyl]-; 1256786-87-4; 3-Acetyl-5-difluoromethylpyridine
EINECS	Contact for details

Quality Control

Every batch of 1-(5-Difluoromethyl-Pyridin-3-Yl)-Ethanone is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with lot-specific data are provided to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. For long-term storage, it is recommended to keep the material at 2-8°C under an inert atmosphere. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.