Description

2-Chloro-5-Fluoropyridine-4-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the precise construction of complex, fluorinated heterocyclic scaffolds, which are critical motifs in advanced material and pharmaceutical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing fluorinated pyridine cores.
• Agrochemical Synthesis: Used to construct active ingredients for crop protection agents, leveraging the biological activity of fluorinated heterocycles.
• Material Science Research: Serves as a building block for creating advanced organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology Probes: Enables the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: A critical reagent for CROs and CDMOs specializing in the production of complex, bespoke organic molecules.

Basic Information

Product Name	2-Chloro-5-Fluoropyridine-4-Boronic Acid Pinacol Ester
CAS No.	1256360-62-9
Molecular Formula	C11H14BClFNO2
Molecular Weight	255.50 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(2-chloro-5-fluoropyridin-4-yl)-1,3,2-dioxaborolane; 2-Chloro-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (2-Chloro-5-fluoropyridin-4-yl)boronic acid pinacol ester; 2-Chloro-5-fluoro-4-pyridineboronic acid pinacol ester; Pinacol (2-chloro-5-fluoropyridin-4-yl)boronate; CAS 1256360-62-9; 2-Chloro-5-fluoropyridine-4-boronic acid, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoropyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.