Description

5-Borono-6-Fluoropicolinic Acid is a high-value, multifunctional heterocyclic building block containing both boronic acid and fluorine functionalities. This compound is critical for modern synthetic chemistry, enabling the construction of complex molecules through versatile cross-coupling reactions. It is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and molecular tags for studying enzyme function and protein interactions.
• PET (Positron Emission Tomography) Tracer Development: The fluorine-18 labeled analog is of significant interest for radiopharmaceutical synthesis in diagnostic imaging.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring specialized boronic acid derivatives.

Basic Information

Product Name	5-Borono-6-Fluoropicolinic Acid
CAS No.	1256355-13-1
Molecular Formula	C6H5BFNO4
Molecular Weight	184.92 g/mol
Synonyms	6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinic acid (protected form); 5-Borono-6-fluoro-2-pyridinecarboxylic acid; 6-Fluoro-5-boronopicolinic acid; 2-Carboxy-6-fluoro-3-pyridineboronic acid; 6-Fluoro-5-borono-2-pyridinecarboxylic acid; 5-(Dihydroxyboryl)-6-fluoropicolinic acid
EINECS	Contact for details

Quality Control

Our 5-Borono-6-Fluoropicolinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially air-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.