Description

p-Coumaric Acid-1,2,3-13C3 is a stable isotope-labeled analog of the naturally occurring phenolic acid, p-coumaric acid, where three carbon atoms are enriched with the 13C isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry, enabling precise and accurate measurement of its unlabeled counterpart in complex biological and chemical matrices. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and food science industries who require definitive analytical data for method development, validation, and metabolic studies.

Application

• Quantitative Mass Spectrometry (MS) Internal Standard: Primary application for accurate quantification of p-coumaric acid in LC-MS/MS and GC-MS analyses.
• Metabolic Pathway Tracing: Used in biomedical and plant science research to study the biosynthesis, absorption, distribution, metabolism, and excretion (ADME) of phenolic compounds.
• Pharmaceutical Impurity Profiling and PK/PD Studies: Enables precise tracking of drug metabolites derived from coumaric acid scaffolds in pharmacokinetic and pharmacodynamic research.
• Food and Beverage Analysis: Critical for quantifying natural antioxidants and flavor precursors in products like wine, honey, fruits, and whole grains for quality and authenticity testing.
• Nutraceutical and Cosmetic Ingredient Analysis: Ensures accurate assay of p-coumaric acid content in dietary supplements and cosmetic formulations claiming antioxidant benefits.
• Environmental and Agricultural Science: Used to study the degradation and fate of phenolic acids in soil and plant systems.

Basic Information

Product Name	p-Coumaric Acid-1,2,3-13C3
CAS No.	1255644-51-9
Molecular Formula	C9H8O3 (with three 13C atoms at positions 1, 2, 3 of the propene chain)
Molecular Weight	~167.1 g/mol (exact mass depends on enrichment level)
Synonyms	(E)-3-(4-Hydroxyphenyl)-2-propenoic-1,2,3-13C3 acid; 4-Hydroxycinnamic-1,2,3-13C3 acid; (E)-p-Coumaric-1,2,3-13C3 acid; 13C3-Labeled p-Coumaric Acid; Isotopic Internal Standard for p-Coumaric Acid; 4-Coumaric-1,2,3-13C3 acid; [13C3]-p-Coumaric Acid
EINECS	Contact for details

Quality Control

Every batch of p-Coumaric Acid-1,2,3-13C3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR, HPLC, and mass spectrometry to confirm structure, enrichment level, and absence of unlabeled impurities. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for identity, purity (HPLC), isotopic enrichment, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure and isotopic pattern
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C (at specified positions)
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.