Description

Unc0638 CAS NO 1255580-76-7 is a potent and selective small molecule inhibitor of the lysine methyltransferase G9a (EHMT2), a key epigenetic regulator. This compound is a critical research tool for investigating the role of histone methylation in gene silencing, cellular differentiation, and disease pathogenesis. It is primarily utilized by researchers in the fields of oncology, neuroscience, and stem cell biology for target validation and mechanistic studies.

Application

• Epigenetics Research: A fundamental tool for studying histone H3 lysine 9 (H3K9) methylation dynamics and its impact on chromatin structure and gene expression.
• Cancer Biology Studies: Used to probe the role of G9a in tumor progression, metastasis, and drug resistance, supporting the development of novel epigenetic therapies.
• Neuroscientific Investigations: Applied in models to understand G9a's function in neural development, synaptic plasticity, and neurological disorders.
• Stem Cell & Developmental Biology: Essential for research into epigenetic reprogramming, cellular differentiation, and the maintenance of pluripotency.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) for identifying novel G9a inhibitors.
• Pharmacology & Target Validation: Used in vitro and in vivo to validate G9a as a therapeutic target across various disease models.

Basic Information

Product Name	Unc0638
CAS No.	1255580-76-7
Molecular Formula	C₂₄H₃₀N₆O₂
Molecular Weight	434.54 g/mol
Synonyms	UNC0638; G9a Inhibitor UNC0638; 1-Cyclohexyl-6-(4-morpholinylmethyl)-3-[[5-(1-pyrrolidinyl)-2-pyridinyl]methyl]-2,4(1H,3H)-pyrimidinedione; EHMT2 Inhibitor UNC0638; (1-Cyclohexyl-6-((4-morpholinomethyl)-3-((5-(pyrrolidin-1-yl)pyridin-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione); Lysine Methyltransferase G9a Inhibitor I
EINECS	Contact for details

Quality Control

Our Unc0638 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and NMR/LC-MS for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and potency is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass)	Conforms (M+H+: 435.2)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.