Description

Pf-4708671 is a potent and selective small molecule inhibitor of the p70 ribosomal protein S6 kinase 1 (S6K1), a key component of the mTOR signaling pathway. This compound is a critical research tool for investigating cellular processes related to growth, proliferation, and metabolism, particularly in the context of cancer, metabolic disorders, and aging. It is essential for academic researchers, pharmaceutical R&D teams, and biotechnology companies engaged in signal transduction research and drug discovery programs.

Application

• Biochemical Research: Used as a selective probe to study the specific roles of S6K1 in the mTORC1 signaling cascade, helping to delineate its function from other downstream effectors.
• Oncology Research: Employed in in vitro and in vivo studies to investigate tumor cell proliferation, survival, and the potential of S6K1 as a therapeutic target in various cancers.
• Metabolic Disease Studies: Applied in research models to understand the role of mTOR/S6K1 signaling in insulin resistance, glucose homeostasis, and lipid metabolism.
• Cell Biology & Physiology: Utilized to explore S6K1's involvement in cellular processes such as protein synthesis, ribosome biogenesis, and cell size regulation.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design and screening of novel S6K1 inhibitors in preclinical development pipelines.

Basic Information

Product Name	Pf-4708671
CAS No.	1255517-76-0
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	PF-4708671; 6-(4-Bromophenyl)imidazo[1,2-a]pyrazin-8-amine; S6K Inhibitor (PF-4708671); p70S6K Inhibitor; Ribosomal protein S6 kinase β-1 inhibitor; S6K1 Inhibitor; 1H-Imidazo[1,2-a]pyrazin-8-amine, 6-(4-bromophenyl)-
EINECS	Contact for details

Quality Control

Our Pf-4708671 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) containing lot-specific data is provided with every shipment to support your research integrity and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.