Description

(E)-3-(2,3-Difluorophenyl)Acrylaldehyde is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the difluorophenyl and α,β-unsaturated aldehyde moieties offer versatile reactivity. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the difluorophenyl group.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chiral ligands, organocatalysts, and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers with tailored electronic and optical properties.
• Cross-Coupling Reactions: The acrylaldehyde group acts as a Michael acceptor or can be further functionalized via palladium-catalyzed reactions for carbon-carbon bond formation.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in organic molecules.

Basic Information

Product Name	(E)-3-(2,3-Difluorophenyl)Acrylaldehyde
CAS No.	1254840-98-6
Molecular Formula	C9H6F2O
Molecular Weight	168.14 g/mol
Synonyms	(E)-3-(2,3-Difluorophenyl)propenal; 2,3-Difluorocinnamaldehyde; trans-3-(2,3-Difluorophenyl)-2-propenal; (E)-3-(2,3-Difluorophenyl)-2-propen-1-al; 2-Propenal, 3-(2,3-difluorophenyl)-, (2E)-; (E)-3-(2,3-Difluorophenyl)acrylaldehyde; (E)-2,3-Difluorocinnamaldehyde
EINECS	Contact for details

Quality Control

Our (E)-3-(2,3-Difluorophenyl)Acrylaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its properties of being easily oxidized (store under inert atmosphere) and light-sensitive, it is recommended to handle under an inert atmosphere (e.g., nitrogen or argon) and minimize exposure to air and light during use. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Purity (GC)	≥ 97.0% (Area %)
Isomeric Purity ((E)-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.