Description

Alicapistat (Synonyms: Abt-957) is a high-purity, small molecule pharmaceutical intermediate and research chemical. This compound is of significant interest for its role in the development of novel therapeutic agents, particularly in the field of protease inhibition. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in advanced synthesis. The product is supplied under stringent quality control to ensure reliability for critical research and development applications.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel drug candidates, particularly those targeting specific proteases.
• Biochemical Assay Development: Used as a tool compound or inhibitor in enzymatic assays to study biological pathways and validate drug targets.
• Preclinical Studies: Employed in in vitro and in vivo studies to investigate pharmacokinetics, pharmacodynamics, and initial efficacy of potential therapeutics.
• Process Chemistry & Scale-Up: Acts as a building block for process chemists during the optimization and scale-up of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and molecular biology.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP or non-GMP production of clinical trial materials.

Basic Information

Product Name	Alicapistat
CAS No.	1254698-46-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Abt-957; ABT957; 1254698-46-8; Alicapistat (USAN); UNII-2Q5K2T8Q4U; 2Q5K2T8Q4U; (3S,3aS,6aR)-3-[(2S)-2-[[(2S)-1-[(2S)-2-[(Methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]carbonylamino]-3-methylbutanoyl]hexahydrocyclopenta[b]pyrrole-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our Alicapistat is manufactured and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.