Description

4-Bromo-2-Chloro-1-(Difluoromethyl)Benzene is a high-value, multi-functional halogenated benzene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and difluoromethyl substituents, makes it an essential intermediate for introducing specific halogenated motifs into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials requiring specific halogenated aromatic units.
• Cross-Coupling Reactions: The bromine and chlorine atoms provide orthogonal reactivity for sequential Suzuki, Stille, or Buchwald-Hartwig amination reactions, enabling complex molecule assembly.
• Fluorine Chemistry: The difluoromethyl group acts as a valuable bioisostere, making this compound vital for structure-activity relationship (SAR) studies in drug discovery.

Basic Information

Product Name	4-Bromo-2-Chloro-1-(Difluoromethyl)Benzene
CAS No.	1254034-23-5
Molecular Formula	C7H4BrClF2
Molecular Weight	241.46 g/mol
Synonyms	1-Bromo-4-chloro-3-(difluoromethyl)benzene; 2-Chloro-4-bromo-α,α-difluorotoluene; 4-Bromo-2-chloro-α,α-difluorotoluene; (Difluoromethyl)-4-bromo-2-chlorobenzene; 3-(Difluoromethyl)-4-bromochlorobenzene; Benzene, 4-bromo-2-chloro-1-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chloro-1-(Difluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.