Description

Amg 511 CAS NO 1253573-53-3 is a potent and selective small-molecule inhibitor of the p21-activated kinase 4 (PAK4). This compound is a critical research tool for investigating the PAK4 signaling pathway, which plays a significant role in cell proliferation, survival, and cytoskeletal dynamics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurology, and metabolic disease research.

Application

• Biochemical Research: Used as a selective probe to study the biological functions and signaling mechanisms of PAK4 in vitro.
• Oncology Research: Investigated for its potential to inhibit cancer cell growth, invasion, and metastasis in preclinical cellular and animal models.
• Drug Discovery: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for developing novel PAK4-targeted therapeutics.
• Neurological Disease Research: Applied in studies exploring the role of PAK4 in neuronal development, synaptic function, and neurodegenerative conditions.
• Signal Transduction Studies: Essential for dissecting the PAK4-mediated pathways involved in cell motility, morphology, and survival.

Basic Information

Product Name	Amg 511
CAS No.	1253573-53-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	AMG-511; AMG 511; 2-[[4-Amino-5-(3-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-3-yl]amino]-N-methylbenzamide; PAK4 Inhibitor AMG-511; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 5-(3-methoxyphenyl)-3-[[2-(methylcarbamoyl)phenyl]amino]-
EINECS	Contact for details

Quality Control

Our Amg 511 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.