Description

2-Fluoro-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is critically needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating novel bidentate ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials requiring specific fluorinated pyridine motifs.
• Chemical Biology & Probe Design: Utilized to create molecular probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Pyridine-3-Boronic Acid
CAS No.	1253569-51-5
Molecular Formula	C7H4BF4NO2
Molecular Weight	208.92 g/mol
Synonyms	[2-Fluoro-5-(trifluoromethyl)pyridin-3-yl]boronic acid; 3-Borono-2-fluoro-5-(trifluoromethyl)pyridine; 2-Fluoro-5-trifluoromethyl-3-pyridineboronic acid; 2-Fluoro-5-(trifluoromethyl)-3-pyridinylboronic acid; 2-Fluoro-5-(trifluoromethyl)pyridine-3-boronic acid pinacol ester (common derivative); 3-Pyridineboronic acid, 2-fluoro-5-(trifluoromethyl)-; 1253569-51-5
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring research-grade to GMP-standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.