Description

Gsk-7975A is a high-purity, small-molecule chemical compound widely utilized as a key research tool in pharmacological studies. Its primary value lies in its function as a potent and selective inhibitor of store-operated calcium entry (SOCE), specifically targeting Orai channels. This makes it an essential reagent for researchers and pharmaceutical developers investigating calcium signaling pathways, immune cell activation, and related disease mechanisms. Industries that require this compound include pharmaceutical R&D, biotechnology, and academic research institutions focused on immunology, neurology, and cardiovascular biology.

Application

• Pharmacological Research: A critical tool for studying the role of store-operated calcium entry (SOCE) in various cellular processes.
• Immunology Studies: Used to investigate T-cell and mast cell activation, cytokine production, and immune response modulation.
• Neurological Research: Applied in models to understand calcium signaling in neurons and its implications for neurodegenerative conditions.
• Cardiovascular Research: Employed to examine calcium homeostasis in cardiac and vascular smooth muscle cells.
• Drug Discovery & Development: Serves as a reference compound and positive control in screening assays for novel SOCE inhibitors.
• Cell Biology: Utilized in fundamental research on calcium-dependent gene expression, cell proliferation, and apoptosis.

Basic Information

Product Name	Gsk-7975A
CAS No.	1253186-56-9
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	GSK-7975A; GSK7975A; 2-[(3,5-Bis-trifluoromethyl-phenyl)-methylsulfanyl]-6-(4-ethyl-piperazin-1-yl)-4-pyrimidinamine; 6-(4-Ethylpiperazin-1-yl)-2-({[3,5-bis(trifluoromethyl)phenyl]methyl}sulfanyl)pyrimidin-4-amine; SOCE Inhibitor; Orai Channel Blocker
EINECS	Contact for details

Quality Control

Every batch of Gsk-7975A is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards expected for research-grade biochemicals, supporting reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.