Description

Tubastatin-A CAS NO 1252003-15-8 is a potent, cell-permeable, and highly selective inhibitor of histone deacetylase 6 (HDAC6). This compound matters as a critical research tool for investigating the role of HDAC6 in cellular processes such as aggresome formation, cell motility, and immune synapse regulation. It is primarily needed by researchers and pharmaceutical developers in the fields of oncology, neurodegenerative disease, and immunology for both basic research and drug discovery applications.

Application

• Biomedical Research: A key reagent for studying HDAC6-specific biology, including microtubule dynamics, protein trafficking, and chaperone function.
• Oncology Research: Used to investigate the role of HDAC6 in cancer cell proliferation, metastasis, and resistance mechanisms, supporting the development of novel cancer therapeutics.
• Neurodegenerative Disease Models: Applied in research on Alzheimer's, Parkinson's, and Huntington's diseases to explore HDAC6's involvement in tau pathology and protein aggregate clearance.
• Immunology Studies: Utilized to examine HDAC6 function in immune cell activation, cytokine production, and immune synapse formation.
• Drug Discovery & Development: Serves as a reference standard and a lead compound for designing and screening new HDAC6-selective inhibitors.
• Chemical Biology: Employed in mechanistic studies to understand epigenetic regulation and validate HDAC6 as a therapeutic target in various disease pathways.

Basic Information

Item	Detail
Product Name	Tubastatin-A
CAS No.	1252003-15-8
Molecular Formula	C20H20N4O2
Molecular Weight	348.40 g/mol
Synonyms	Tubastatin A; Tubastatin A HCl; N-Hydroxy-4-[[(2S)-2-[[(1R)-2,3-Dihydro-1H-inden-1-yl]amino]-2-oxoethyl]amino]methyl]benzamide; HDAC6 Inhibitor, Tubastatin A; (R)-N1-Hydroxy-4-((2-((S)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-2-oxoethyl)carbamoyl)benzamide; Tubacin analog; AG-K-100028; BML-281
EINECS	Contact for details

Quality Control

Our Tubastatin-A is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.