Description

4-(Trifluoromethyl)Oxan-4-Ol is a high-value fluorinated heterocyclic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring a trifluoromethyl group and a tertiary alcohol within a tetrahydropyran ring, makes it a versatile intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty monomers and polymers, contributing to the development of materials with specific surface properties, chemical resistance, or optical characteristics.
• Ligand and Catalyst Development: Employed in the synthesis of complex ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Building Block: An essential reagent for introducing the CF3 moiety into complex organic architectures in discovery chemistry.

Basic Information

Product Name	4-(Trifluoromethyl)Oxan-4-Ol
CAS No.	1251358-35-6
Molecular Formula	C7H11F3O2
Molecular Weight	184.16 g/mol
Synonyms	4-(Trifluoromethyl)tetrahydro-2H-pyran-4-ol; 4-Hydroxy-4-(trifluoromethyl)tetrahydropyran; 4-Trifluoromethyl-4-hydroxytetrahydropyran; Tetrahydropyran-4-ol, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-4-hydroxytetrahydropyran; 4-TFMP-OH (abbrev.)
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Oxan-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.