Description

(3-(Trifluoromethyl)Pyridin-2-Yl)Methanamine Dihydrochloride CAS NO 1250443-60-7 is a high-purity, organofluorine building block featuring a pyridine core substituted with a trifluoromethyl group and an amine hydrochloride salt. This compound is critical for medicinal chemistry and agrochemical research, where its unique trifluoromethyl group enhances metabolic stability, lipophilicity, and binding affinity in target molecules. It is primarily needed by pharmaceutical R&D teams, agrochemical innovators, and contract research organizations (CROs) for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of small molecule drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating chemical probes and affinity tags to study protein function and enzyme inhibition.
• Material Science Precursor: Employed in the research of advanced organic electronic materials and liquid crystals due to its electron-deficient aromatic system.
• Custom Synthesis & Scale-Up: A starting material for contract manufacturing organizations (CMOs) offering custom synthesis services from gram to kilogram scale.
• Library Synthesis for HTS: An important reagent for constructing diverse compound libraries used in high-throughput screening (HTS) campaigns.

Basic Information

Product Name	(3-(Trifluoromethyl)Pyridin-2-Yl)Methanamine Dihydrochloride
CAS No.	1250443-60-7
Molecular Formula	C7H8Cl2F3N2
Molecular Weight	251.05 g/mol
Synonyms	2-(Aminomethyl)-3-(trifluoromethyl)pyridine dihydrochloride; 1-[3-(Trifluoromethyl)pyridin-2-yl]methanamine dihydrochloride; (3-Trifluoromethyl-2-pyridyl)methanamine dihydrochloride; 2-Pyridinemethanamine, 3-(trifluoromethyl)-, dihydrochloride; (3-CF3-Pyridin-2-yl)methanamine HCl; 2-(Aminomethyl)-3-trifluoromethylpyridine hydrochloride; α-Amino-3-(trifluoromethyl)-2-picoline dihydrochloride
EINECS	Contact for details

Quality Control

Our (3-(Trifluoromethyl)Pyridin-2-Yl)Methanamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.