Description

(2,6-Difluorophenyl)Phosphonic Acid Diethyl Ester is a high-value organophosphorus compound characterized by its difluorinated aromatic ring and phosphonate ester functionality. This structure makes it a versatile and critical building block in advanced chemical synthesis, particularly for introducing phosphonate groups with enhanced electronic and steric properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics where the phosphonate moiety acts as a bioisostere for phosphate or carboxylate groups.
• Agrochemical Active Ingredient Precursor: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators, leveraging the fluorine atoms for improved metabolic stability and membrane permeability.
• Ligand and Catalyst Synthesis: Serves as a precursor for phosphonic acid-based ligands used in coordination chemistry, catalysis, and the preparation of metal-organic frameworks (MOFs).
• Material Science: Employed in the surface modification of materials, creation of flame retardants, and development of specialty polymers with specific adhesion or dielectric properties.
• Chemical Research: A valuable reagent in organic synthesis for Horner-Wadsworth-Emmons (HWE) olefination reactions and other carbon-carbon bond forming processes.

Basic Information

Product Name	(2,6-Difluorophenyl)Phosphonic Acid Diethyl Ester
CAS No.	1250397-29-5
Molecular Formula	C10H13F2O3P
Molecular Weight	250.18 g/mol
Synonyms	Diethyl (2,6-Difluorophenyl)phosphonate; (2,6-Difluorophenyl)phosphonic Acid Diethyl Ester; Diethyl (2,6-Difluorophenyl)phosphonate; Phosphonic Acid, P-(2,6-Difluorophenyl)-, Diethyl Ester; 2,6-Difluorophenylphosphonic Acid Diethyl Ester; Diethyl 2,6-Difluorophenylphosphonate; (2,6-Difluorophenyl)phosphonate Diethyl Ester
EINECS	Contact for details

Quality Control

Every batch of (2,6-Difluorophenyl)Phosphonic Acid Diethyl Ester is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support cGMP and ISO guided manufacturing for applications requiring the highest level of quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.