Description

3-(2,2-Difluoro-Ethoxy)-Pyridine-2-Carboxylic Acid is a high-purity, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a difluoroethoxy side chain, is engineered to impart desirable metabolic stability and lipophilicity in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the design and synthesis of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis, enabling novel synthetic transformations.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals or polymers, where fluorinated aromatic units modify physical properties.
• Chemical Biology Probes: Utilized as a building block for developing molecular probes and tags to study biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards for clinical and commercial supply.

Basic Information

Item	Details
Product Name	3-(2,2-Difluoro-Ethoxy)-Pyridine-2-Carboxylic Acid
CAS No.	1250216-31-9
Molecular Formula	C8H7F2NO3
Molecular Weight	203.14 g/mol
Synonyms	2-Pyridinecarboxylic acid, 3-(2,2-difluoroethoxy)-; 3-(2,2-Difluoroethoxy)picolinic acid; 3-(Difluoroethoxy)-2-pyridinecarboxylic acid; 2-Carboxy-3-(2,2-difluoroethoxy)pyridine; Picolinic acid, 3-(2,2-difluoroethoxy)-; 1250216-31-9; 3-(2,2-Difluoroethoxy)pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(2,2-Difluoro-Ethoxy)-Pyridine-2-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and cGMP-grade synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity, identity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is compatible with strong acid/organic solvent conditions but should be handled with standard laboratory precautions to avoid moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.