Description

(1-Acetylpiperidin-4-Yl)Methanesulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate and chemical building block. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those targeting neurological and metabolic disorders.
• Sulfonamide & Sulfonate Synthesis: Acts as a versatile reagent for introducing the methanesulfonyl chloride moiety to create sulfonamide or sulfonate ester derivatives.
• Medicinal Chemistry & SAR Studies: Used in structure-activity relationship (SAR) explorations to optimize the potency and selectivity of lead compounds.
• Protease Inhibitor Development: Serves as a precursor in the development of protease inhibitors and other enzyme-targeted therapies.
• Chemical Biology Probes: Employed in the synthesis of chemical probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	(1-Acetylpiperidin-4-Yl)Methanesulfonyl Chloride
CAS No.	1249687-64-6
Molecular Formula	C9H16ClNO3S
Molecular Weight	253.75 g/mol
Synonyms	4-(Chlorosulfonylmethyl)-1-acetylpiperidine; 1-Acetyl-4-(chlorosulfonylmethyl)piperidine; 4-(Methanesulfonyl chloride)-1-acetylpiperidine; (1-Acetyl-4-piperidinyl)methanesulfonyl chloride; N-Acetyl-4-piperidinemethanesulfonyl chloride; 1-Piperidineacetic acid, 4-(chlorosulfonylmethyl)-, 1-acetyl-; (1-Acetylpiperidin-4-yl)methanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our (1-Acetylpiperidin-4-Yl)Methanesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.