Description

Desacetyl Diltiazem-D6 is a deuterium-labeled analog of a key diltiazem metabolite, serving as a critical internal standard for precise analytical quantification. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in bioanalytical method development and validation.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mstrong style="color:#000">ass Spectrometry (GC-MS) analysis.
• Quantification of desacetyl diltiazem and related metabolites in biological matrices (e.g., plasma, serum, urine) for clinical and preclinical studies.
• Supporting bioanalytical method development and validation in accordance with FDA, EMA, and ICH guidelines.
• Metabolic profiling and drug metabolism and pharmacokinetics (DMPK) research for cardiovascular drug candidates.
• Use in quality control laboratories for the analysis of active pharmaceutical ingredients (APIs) and finished drug products.
• Application in forensic toxicology for the accurate detection and measurement of diltiazem and its metabolites.

Basic Information

Product Name	Desacetyl Diltiazem-D6
CAS No.	1246820-35-8
Molecular Formula	C22H20D6N2O4S
Molecular Weight	420.55 g/mol
Synonyms	(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate-D6; Desacetyl Diltiazem D6; Didesacetyl Diltiazem-D6 (common misnomer); Diltiazem Metabolite (M1) D6; (+)-cis-Desacetyl Diltiazem-D6; 3-Acetyloxy-2,3-dihydro-5-[2-(dimethylamino-d6)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one; Deuterated Desacetyl Diltiazem
EINECS	Contact for details

Quality Control

Every batch of Desacetyl Diltiazem-D6 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, MS, and HPLC. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and identification is provided with each shipment to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.