Description

(S)-Amphetamine-D3 Hydrochloride is a stable isotope-labeled analog of the pharmaceutical compound (S)-amphetamine, where three hydrogen atoms are replaced by deuterium. This high-purity reference material is critical for ensuring analytical accuracy and reliability in quantitative bioanalysis. It is primarily utilized by pharmaceutical research laboratories, forensic toxicology departments, and contract research organizations (CROs) for method development, validation, and as an internal standard in mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of (S)-amphetamine and related substances in biological matrices (e.g., plasma, urine, hair).
• Forensic Toxicology & Doping Control: Essential for developing and validating highly specific and sensitive analytical methods to detect and confirm amphetamine use in forensic and anti-doping applications.
• Pharmacokinetic & Metabolism Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track the fate of the parent drug and differentiate it from endogenous compounds or metabolites.
• Pharmaceutical R&D & Quality Control: Supports method development and validation in drug discovery, formulation stability testing, and impurity profiling of amphetamine-based pharmaceutical products.
• Clinical Research: Enables accurate measurement of drug concentrations in patient samples during clinical trials for dose-response and safety evaluations.
• Reference Material for Calibration: Provides a certified, high-purity standard for calibrating analytical instrumentation and ensuring traceability of measurement results.

Basic Information

Product Name	(S)-Amphetamine-D3 Hydrochloride
CAS No.	1246819-55-5
Molecular Formula	C9H10D3ClN
Molecular Weight	173.69 g/mol
Synonyms	(2S)-1-Phenylpropan-2-amine-α,α,β-D3 hydrochloride; (S)-(+)-Amphetamine-D3 HCl; Dexamphetamine-D3 hydrochloride; (S)-α-Methylbenzeneethanamine-D3 hydrochloride; d-Amphetamine-D3 hydrochloride; (2S)-1-Phenyl-2-aminopropane-D3 hydrochloride; (S)-1-Phenyl-2-propylamine-D3 hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Amphetamine-D3 Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (D3), and high chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the results for assay, isotopic enrichment, and related substances. We ensure compliance with the rigorous standards required for analytical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.