Description

3-Demethyl Thiocolchicine-D3 is a deuterated derivative of a key colchicine analogue, serving as a critical stable isotope-labeled reference standard. This compound is essential for ensuring the accuracy and reliability of quantitative analytical methods in pharmaceutical research and development. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Primary use as a stable isotope-labeled internal standard for the precise quantification of colchicine and its metabolites in biological matrices via LC-MS/MS.
• Critical component in pharmacokinetic and bioanalytical studies to understand drug metabolism and disposition.
• Supporting method development and validation for regulatory submissions to agencies like the FDA and EMA.
• Used in drug discovery research focusing on tubulin polymerization inhibitors and anti-inflammatory agents.
• Application in forensic and clinical toxicology for the accurate detection and measurement of colchicine-related compounds.
• Reference material for quality control and assurance in the production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3-Demethyl Thiocolchicine-D3
CAS No.	1246818-03-0
Molecular Formula	C21H20D3NO5S
Molecular Weight	406.49 g/mol (approx.)
Synonyms	Thiocolchicine-3-O-demethyl-D3; N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide-3-O-demethyl-D3; Deuterated 3-Demethylthiocolchicine; Colchicine derivative-D3; 3-O-Desmethylthiocolchicine-D3; [D3]-3-Demethylthiocolchicine; Stable Isotope Labeled Thiocolchicine Metabolite
EINECS	Contact for details

Quality Control

Every batch of 3-Demethyl Thiocolchicine-D3 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to confirm identity, chemical purity, and isotopic enrichment, ensuring it meets the exacting standards required for use as a reference standard. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results for assay, isotopic purity, and related substances by HPLC and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.