Description

4-(Methylnitrosamino)-1-[(3-Pyridyl)-4-Carboxy]-1-Butanol is a nitrosamine derivative of significant interest in analytical and biochemical research. This compound matters as a key biomarker and reference standard for the study of tobacco-specific nitrosamines (TSNAs) and their metabolic pathways. It is primarily needed by research institutions, diagnostic laboratories, and pharmaceutical companies engaged in toxicology studies, carcinogenesis research, and the development of analytical methods for nitrosamine detection and quantification.

Application

• Biomarker Reference Standard: Serves as a critical calibrant and control in the quantitative analysis of tobacco-specific nitrosamine (TSNA) metabolites in biological samples.
• Toxicology & Carcinogenesis Research: Used in studies investigating the metabolic activation, DNA adduct formation, and carcinogenic mechanisms of nitrosamines.
• Analytical Method Development: Essential for developing and validating sensitive LC-MS/MS, GC-MS, or HPLC methods for nitrosamine detection in complex matrices.
• Clinical & Epidemiological Studies: Employed as an analytical standard to measure exposure to tobacco smoke and assess associated health risks in population studies.
• Pharmaceutical Impurity Testing: Acts as a reference compound in the development of methods to detect and quantify potentially genotoxic nitrosamine impurities in active pharmaceutical ingredients (APIs) and drug products, supporting compliance with regulatory guidelines (e.g., ICH M7).
• Biochemical Research: Utilized in enzymatic studies related to the metabolism and detoxification pathways of nitrosamines.

Basic Information

Product Name	4-(Methylnitrosamino)-1-[(3-Pyridyl)-4-Carboxy]-1-Butanol
CAS No.	1246817-89-9
Molecular Formula	C12H15N3O3
Molecular Weight	249.27 g/mol
Synonyms	NNAL-Glucuronide (incorrect but common mis-association); 4-(Methylnitrosamino)-1-(3-pyridyl)-4-carboxy-1-butanol; NNAL-COOH; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-4-carboxylic acid; NNAL Acid; NNAL-Carboxylic Acid; Tobacco-specific nitrosamine metabolite; TSNA biomarker
EINECS	Contact for details

Quality Control

Our high-purity reference standards are produced under a strict quality management system. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, LC-MS, and NMR to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided, listing batch-specific results for assay, impurities, and other critical parameters to ensure traceability and reliability for your research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.