Description

Hydroxy Bosentan-D6 is a deuterium-labeled isotopologue of a key metabolite of the endothelin receptor antagonist bosentan. This stable isotope-labeled compound is essential for precise quantitative analysis in pharmacokinetic and metabolic studies, ensuring high accuracy and reliability in research data. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and bioanalytical method validation.

Application

• Internal standard for the quantitative bioanalysis of bosentan and its metabolites using LC-MS/MS.
• Use in drug metabolism and pharmacokinetics (DMPK) studies to track metabolic pathways.
• Critical component in the development and validation of GLP-compliant bioanalytical methods.
• Supporting clinical trial research for accurate measurement of drug concentrations in biological matrices.
• Metabolite profiling and identification in preclinical and clinical development stages.
• Reference material for quality control in pharmaceutical manufacturing of bosentan-based therapies.

Basic Information

Product Name	Hydroxy Bosentan-D6
CAS No.	1246817-57-1
Molecular Formula	C27H24D6N2O6S
Molecular Weight	~ 516.61 g/mol
Synonyms	4-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide-d6; Bosentan Hydroxy Metabolite-d6; (R)-Hydroxy Bosentan-d6; RO 48-5033 metabolite-d6; Deuterated Hydroxy Bosentan; Bosentan-d6 Metabolite
EINECS	Contact for details

Quality Control

Our Hydroxy Bosentan-D6 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from NMR, HPLC, and MS analysis. We adhere to relevant industry standards to guarantee reliable performance as an internal standard.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.