Description

Vincristine-D3 Sulfate is a deuterated analog of the potent vinca alkaloid antineoplastic agent, vincristine sulfate. This stable isotope-labeled compound is essential for high-precision analytical and pharmacokinetic studies, providing an internal standard for accurate quantification and metabolic profiling. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and academic institutions engaged in oncology drug development and bioanalytical method validation.

Application

• Internal standard for the quantitative analysis of vincristine sulfate in biological matrices (e.g., plasma, serum) using LC-MS/MS.
• Metabolic stability and pharmacokinetic (PK) studies in drug discovery and development programs.
• Use in bioequivalence and bioavailability studies for generic oncology drug formulations.
• Supporting clinical research and therapeutic drug monitoring (TDM) protocols.
• Isotope dilution mass spectrometry for the precise determination of vincristine levels.
• Deuterated reference material for forensic and anti-doping analysis.

Basic Information

Product Name	Vincristine-D3 Sulfate
CAS No.	1246817-10-6
Molecular Formula	C46H53D3N4O10 • H2SO4
Molecular Weight	~ 929.08 g/mol (for monoisotopic mass)
Synonyms	22-Oxovincaleukoblastine-D3 Sulfate; Leurocristine-D3 Sulfate; LCR-D3 Sulfate; Vincasar-D3; Oncovin-D3 Sulfate; (3aR,3a1R,4R,5S,5aR,10bR)-Methyl 4-acetoxy-3a-ethyl-9-((5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate-D3 Sulfate
EINECS	Contact for details

Quality Control

Our Vincristine-D3 Sulfate is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS, to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, purity, and identity is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C, or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.